Myxoid chondrosarcoma of the phalanx with an EWS translocation: a case report and review of the literature.

نویسندگان

  • David B Bumpass
  • Michael Kyriakos
  • David A Rubin
  • Paul R Manske
  • Charles A Goldfarb
چکیده

Myxoid chondrosarcoma of the phalanx with an EWS translocation: A case report and review of the literature.

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Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21).

Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by recurrent t(9;22) or t(9;17) translocations resulting in fusions of the NH2-terminal transactivation domains of EWS or TAF2N to the entire TEC protein. We report here an EMC with a novel translocation t(9; 15)(q22;q21) and a third type of TEC-containing fusion gene. The chimeric transcript encodes a protein in which the first 108 ...

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عنوان ژورنال:
  • The Journal of bone and joint surgery. American volume

دوره 93 6  شماره 

صفحات  -

تاریخ انتشار 2011