Myxoid chondrosarcoma of the phalanx with an EWS translocation: a case report and review of the literature.
نویسندگان
چکیده
Myxoid chondrosarcoma of the phalanx with an EWS translocation: A case report and review of the literature.
منابع مشابه
Chondrosarcoma of cranial vault: case report and review of literature
Chondrosarcoma is a rare malignant cartilage forming tumour usually arising from long bones and rarely seen in cranium. In cranium it is seen to commonly arises from skull base with skull vault being a highly unusual site. We report a case of a 30-year female presenting with complaints of headache for 6 months found to have a large chondrosarcoma in right fronto-parietal region which is an extr...
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متن کاملFusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by a recurrent t(9;22)(q22;q12) translocation, resulting in the fusion of the EWS gene in 22q12 and the TEC gene in 9q22. Here we report that a third member of the EWS, TLS/FUS gene family, TAF2N, can replace EWS as a fusion partner to TEC in EMC. Two tumors, one with a novel t(9;17)(q22;q11) variant translocation and one with an app...
متن کاملMolecular Dissection Using Array Comparative Genomic Hybridization and Clinical Evaluation of An Infertile Male Carrier of An Unbalanced Y;21 Translocation: A Case Report and Review of The Literature
Chromosomal defects are relatively frequent in infertile men however, translocations between the Y chromosome and autosomes are rare and less than 40 cases of Y-autosome translocation have been reported. In particular, only three individuals has been described with a Y;21 translocation, up to now. We report on an additional case of an infertile man in whom a Y;21 translocation was associated wi...
متن کاملFusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21).
Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by recurrent t(9;22) or t(9;17) translocations resulting in fusions of the NH2-terminal transactivation domains of EWS or TAF2N to the entire TEC protein. We report here an EMC with a novel translocation t(9; 15)(q22;q21) and a third type of TEC-containing fusion gene. The chimeric transcript encodes a protein in which the first 108 ...
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عنوان ژورنال:
- The Journal of bone and joint surgery. American volume
دوره 93 6 شماره
صفحات -
تاریخ انتشار 2011